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Gene Expression Data
Assay Details
Assay
Reference: J:74155 Kagoshima M, et al., Diverse gene expression and function of semaphorins in developing lung: positive and negative regulatory roles of semaphorins in lung branching morphogenesis. Genes Cells. 2001 Jun;6(6):559-71
Assay type: RNA in situ
MGI Accession ID: MGI:6361496
Gene symbol: Sema3a
Gene name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
Probe: Sema3A probe5
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 1A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: lung mesenchyme Strong Regionally restricted 1A Prominent expression in mesenchyme. High levels of expresion in mesenchyme around airway epithelium, especially in the distal portion of lung.
Specimen 1B: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lung mesenchyme Strong Regionally restricted 1B Prominent expression in mesenchyme. High levels of expresion in mesenchyme around airway epithelium, especially in the distal portion of lung.
Specimen 1C: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: lung mesenchyme Strong Regionally restricted 1C Prominent expression in mesenchyme. High levels of expresion in mesenchyme around airway epithelium, especially in the distal portion of lung.
Specimen 2A: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lung mesenchyme Weak 2A Expression in mesenchyme decreased at later stages of development.
TS23: bronchiole epithelium Strong 2A Strong expression in epithelium of intermediate-sized bronchioles.
Specimen 2B: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: lung mesenchyme Weak 2B Expression in mesenchyme decreased at later stages of development.
TS23: bronchiole epithelium Strong 2B Strong expression in epithelium of intermediate-sized bronchioles.
Specimen 3A: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: lung mesenchyme Weak 3A Expression in mesenchyme decreased at later stages of development.
TS25: lung epithelium Weak 3A Epithelial gene expression slightly down-regulated, but still detectable.
TS25: terminal bronchiole Present 3A Expression in terminal buds.
Specimen 3B: embryonic day 17.5 (more )
Structure Level Pattern Image Note
TS25: lung mesenchyme Weak 3B Expression in mesenchyme decreased at later stages of development.
TS25: lung epithelium Weak 3B Epithelial gene expression slightly down-regulated, but still detectable.
TS25: terminal bronchiole Present 3B Expression in terminal buds.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory