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Gene Expression Data
Assay Details
Assay
Reference: J:258043 Wang Y, et al., N(6)-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat Neurosci. 2018 Feb;21(2):195-206
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6358411
Gene symbol: Satb2
Gene name: special AT-rich sequence binding protein 2
Antibody: anti-Satb2 (ab92446)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Results
Specimen 4c Mettl14f/f: postnatal day 0; Mettl14tm1.1Czhao/Mettl14tm1.1Czhao (more )
Structure Level Pattern Image Note
TS27: cortical layer II Present 4c merge Mettl14f/f , 4c Mettl14f/f
TS27: cortical layer III Present 4c merge Mettl14f/f , 4c Mettl14f/f
TS27: cortical layer IV Present 4c merge Mettl14f/f , 4c Mettl14f/f
Specimen 4c Mettl14f/f;Nestin-cre: postnatal day 0; Mettl14tm1.1Czhao/Mettl14tm1.1Czhao, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cortical layer II Present Regionally restricted 4c merge Mettl14f/f;Nestin-cre , 4c Mettl14f/f;Nestin-cre There is a 34% decrease in the number of expressing neurons in this mutant mice versus littermate controls.
TS27: cortical layer III Present Regionally restricted 4c merge Mettl14f/f;Nestin-cre , 4c Mettl14f/f;Nestin-cre There is a 34% decrease in the number of expressing neurons in this mutant mice versus littermate controls.
TS27: cortical layer IV Present Regionally restricted 4c merge Mettl14f/f;Nestin-cre , 4c Mettl14f/f;Nestin-cre There is a 34% decrease in the number of expressing neurons in this mutant mice versus littermate controls.
Specimen 4c Mettl14f/+;Nestin-cre: postnatal day 0; Mettl14tm1.1Czhao/Mettl14+, Tg(Nes-cre)1Kln/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cortical layer II Present 4c Mettl14f/+;Nestin-cre , 4c merge Mettl14f/+;Nestin-cre
TS27: cortical layer III Present 4c Mettl14f/+;Nestin-cre , 4c merge Mettl14f/+;Nestin-cre
TS27: cortical layer IV Present 4c Mettl14f/+;Nestin-cre , 4c merge Mettl14f/+;Nestin-cre
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory