Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Vimtm1Sibg
Name:	vimentin; targeted mutation 1, Shigeyoshi Itohara
MGI ID:	MGI:6355955
Synonyms:	VimSA
Gene:	Vim  Location: Chr2:13579122-13587637 bp, + strand  Genetic Position: Chr2, 10.04 cM, cytoband A2
Alliance:	Vimtm1Sibg page

Germline Transmission:	Earliest citation of germline transmission: J:276637
Parent Cell Line:	EB3 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Modified isoform(s)) Mutation:    Nucleotide substitutions   Mutation details: Targeted mutagenesis was used to generate mutations reslting in the substitution of Ser to Ala in the vimentin head domain of the encoded protein at multiple positions. These include codons 6, 24, 38. 46. 55. 64, 65, 71, 72, 82 and 86 in exon 1. (J:276637)

In Mice Carrying this Mutation:

53 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vim Mutation:	37 strains or lines available

Original:	J:276637 Matsuyama M, et al., Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells. J Biol Chem. 2013 Dec 13;288(50):35626-35
All:	2 reference(s)