Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mtx2em1(IMPC)J
Name:	metaxin 2; endonuclease-mediated mutation 1, Jackson
MGI ID:	MGI:6314758
Gene:	Mtx2  Location: Chr2:74656156-74707092 bp, + strand  Genetic Position: Chr2, 44.13 cM, cytoband D
Alliance:	Mtx2em1(IMPC)J page
IMPC:	Mtx2 gene page

Strain of Origin:	C57BL/6NJ
Project Collection:	IMPC

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Intragenic deletion   Mutation details: This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TAAGTTTAGGAAAAGAATGA and CTTACTTGAGCTCTGGTCCG, which resulted in a 406 bp deletion beginning at Chromosome 2 position 74,859,326 bp and ending after 74,859,731 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001238985 (exon 4) and 333 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 45 and early truncation 11 amino acids later. (J:188991) Inheritance:    Not Specified

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mtx2 Mutation:	22 strains or lines available

Original:	J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:	2 reference(s)