Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Chchd10em10Lutzy
Name:	coiled-coil-helix-coiled-coil-helix domain containing 10; endonuclease-mediated mutation 10, Cathy Lutz
MGI ID:	MGI:6295437
Synonyms:	Chchd10R15L
Gene:	Chchd10  Location: Chr10:75768964-75773581 bp, + strand  Genetic Position: Chr10, 38.62 cM
Alliance:	Chchd10em10Lutzy page

Strain of Origin:

C57BL/6NJ

Allele Type:    Endonuclease-mediated (Humanized sequence) Mutation:    Nucleotide substitutions   Mutation details: CRISPR/Cas9 genome editing is used to introduce the R15L substitution (CGC to CTC codon change). In humans, the R15L substitution is associated with amyotrophic lateral sclerosis. (J:101977)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chchd10 Mutation:	16 strains or lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	1 reference(s)