Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Thy1-SNCA*E35K*E46K*E61K)3798Nuber
Name:	transgene insertion 3798, Silke Nuber
MGI ID:	MGI:6281748
Synonyms:	3KL, Thy1-3K alpha S
Transgene:	Tg(Thy1-SNCA*E35K*E46K*E61K)3798Nuber  Location: unknown
Alliance:	Tg(Thy1-SNCA*E35K*E46K*E61K)3798Nuber page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutations:    Insertion, Nucleotide substitutions   Tg(Thy1-SNCA*E35K*E46K*E61K)3798Nuber expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human SNCA (6622) Snca  (MGI:1277151) mutated human gene   Mutation details: The transgene contains a Thy1 promoter sequence directing expression of a modified human alpha synuclein cDNA carrying the E35K, E46K and E61K mutations. Founder line 3798 with low overexpression was subsequently established. (J:268903)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:268903 Nuber S, et al., Abrogating Native alpha-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease. Neuron. 2018 Oct 10;100(1):75-90.e5
All:	3 reference(s)