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Gene Expression Data
Assay Details
Assay
Reference: J:217512 Bessonnard S, et al., Gata6, Nanog and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network. Development. 2014 Oct;141(19):3637-48
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6281371
Gene symbol: Sox17
Gene name: SRY (sex determining region Y)-box 17
Antibody: anti-Sox17 (AF1924)
Detection system: Cy5
Results
Specimen 1A +/+: embryonic day 3.75 (more )
Note: Triple labeled: red - Sox17; green - Nanog (assay MGI:6281190); blue/yellow - Cdx2 (assay MGI:6281373).
Structure Level Pattern Image Note
TS5: inner cell mass Present Non-Uniform 1A upper Sox17 , 1A upper merge Expressed in primitive endoderm progenitors (45% of all inner cell mass cells).
Specimen 1A -/-: embryonic day 3.75; Gata6tm2.2Sad/Gata6tm2.2Sad (more )
Note: Triple labeled: red - Sox17; green - Nanog (assay MGI:6281190); blue/yellow - Cdx2 (assay MGI:6281373).
Structure Level Pattern Image Note
TS5: inner cell mass Absent 1A lower Sox17 , 1A lower merge
Specimen 4A +/-: embryonic day 3.75; Gata6tm2.2Sad/Gata6+ (more )
Note: Data was quantified in Fig. 4B. Triple labeled: red - Sox17; green - Nanog (assay MGI:6281190); blue/yellow - Cdx2 (assay MGI:6281373).
Structure Level Pattern Image Note
TS5: inner cell mass Present 4A Sox17 , 4A merge Large deficit in the specification of primitive endoderm cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory