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Gene Expression Data
Assay Details
Assay
Reference: J:95356 Kettunen P, et al., Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgf{beta}1 regulate semaphorin 3a expression in the dental mesenchyme. Development. 2005 Jan;132(2):323-334
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6270410
Gene symbol: Prph
Gene name: peripherin
Antibody: anti-peripherin
Detection system: Secondary antibody coupled to horseradish peroxidase
Results
Specimen 1B1: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: lower jaw primordium Present Regionally restricted 1B1 Expression is in nerve fibers.
TS19: trigeminal nerve Present Regionally restricted 1B1 Expression is in nerve fibers.
Specimen 1C1: embryonic day 11.5; Sema3atm1Mcf/Sema3atm1Mcf (more )
Structure Level Pattern Image Note
TS19: lower jaw primordium Present Regionally restricted 1C1 Expression is in ectopic nerve fibers.
TS19: trigeminal nerve Present Regionally restricted 1C1 Expression is in ectopic nerve fibers.
Specimen 1B2: embryonic day 12.5 (more )
Note: Early bud stage of tooth development.
Structure Level Pattern Image Note
TS20: trigeminal nerve mandibular division Present 1B2
Specimen 1C2: embryonic day 12.5; Sema3atm1Mcf/Sema3atm1Mcf (more )
Note: Early bud stage of tooth development.
Structure Level Pattern Image Note
TS20: lower jaw primordium Present Regionally restricted 1C2 Expression is in ectopic nerve fibers.
TS20: trigeminal nerve mandibular division Present Regionally restricted 1C2 Expression is in ectopic nerve fibers.
Specimen 1B3: embryonic day 13.5 (more )
Note: Bud stage of tooth development.
Structure Level Pattern Image Note
TS21: trigeminal nerve mandibular division Present 1B3
TS21: lower jaw Present Regionally restricted 1B3 Expression is in the buccal and shorter lingual nerve branches.
Specimen 1C3: embryonic day 13.5; Sema3atm1Mcf/Sema3atm1Mcf (more )
Note: Bud stage of tooth development.
Structure Level Pattern Image Note
TS21: lower jaw molar mesenchyme Present Regionally restricted 1C3 Expression is in ectopic nerve fibers.
TS21: trigeminal nerve mandibular division Present Regionally restricted 1C3 Expression is in ectopic nerve fibers.
Specimen 1B4: embryonic day 14.5 (more )
Note: Cap stage of tooth development.
Structure Level Pattern Image Note
TS22: trigeminal nerve mandibular division Present 1B4
TS22: lower jaw Present Regionally restricted 1B4 Expression is in nerve fibers at the buccal side of the tooth germ and were located in the area between the mesenchymal dental follicle and forming alveolar bone.
Specimen 1C4: embryonic day 14.5; Sema3atm1Mcf/Sema3atm1Mcf (more )
Note: Cap stage of tooth development.
Structure Level Pattern Image Note
TS22: trigeminal nerve mandibular division Present 1C4
TS22: lower jaw Present Regionally restricted 1C4 In this mutant additional nerve fibers were present next to the outer dental epithelium.
TS22: lower jaw tooth dental papilla Present Regionally restricted 1C4 Expression is in nerve fibers.
Specimen 1B5: embryonic day 18.5 (more )
Note: Bell stage of tooth development.
Structure Level Pattern Image Note
TS26: lower jaw Present Regionally restricted 1B5 Expression is in nerve fibers located in the mesenchymal dental follicle target field between the outer dental epithelium and alveolar bone.
TS26: bell stage tooth Present 1B5
TS26: dental sac Present 1B5
TS26: trigeminal nerve mandibular division Present 1B5
TS26: lower jaw tooth dental papilla Present 1B5 Expression is in nerve fibers located in the base of the dental papilla mesenchyme between the epithelial cervical loops.
Specimen 1C5: embryonic day 18.5; Sema3atm1Mcf/Sema3atm1Mcf (more )
Note: Bell stage of tooth development.
Structure Level Pattern Image Note
TS26: trigeminal nerve mandibular division Present 1C5
TS26: lower jaw Present Regionally restricted 1C5 In this mutant additional nerve fibers were present next to the outer dental epithelium and in the dental papilla mesenchyme.
TS26: lower jaw tooth dental papilla Present Regionally restricted 1C5 In this mutant additional nerve fibers were present next to the outer dental epithelium and in the dental papilla mesenchyme.
Specimen not shown: embryonic day 16.5 (more )
Note: Bell stage of tooth development.
Structure Level Pattern Image Note
TS24: trigeminal nerve mandibular division Present
TS24: bell stage tooth Present Regionally restricted Expression is in nerve fibers at the buccal side of the tooth germ and were located in the area between the mesenchymal dental follicle and forming alveolar bone.
TS24: lower jaw Present Regionally restricted Expression is in nerve fibers at the buccal side of the tooth germ and were located in the area between the mesenchymal dental follicle and forming alveolar bone.
Specimen not shown Sema3a-/-: embryonic day 16.5; Sema3atm1Mcf/Sema3atm1Mcf (more )
Note: Bell stage of tooth development.
Structure Level Pattern Image Note
TS24: trigeminal nerve mandibular division Present
TS24: lower jaw Present Regionally restricted In this mutant additional nerve fibers were present next to the outer dental epithelium.
TS24: bell stage tooth Present Regionally restricted In this mutant additional nerve fibers were present.
TS24: lower jaw tooth dental papilla Present Regionally restricted In this mutant additional nerve fibers were present.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory