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Gene Expression Data
Assay Details
Assay
Reference: J:149227 Liu Y, et al., Abnormal development of the neuromuscular junction in Nedd4-deficient mice. Dev Biol. 2009 Jun 1;330(1):153-66
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6200606
Gene symbol: Nedd4
Gene name: neural precursor cell expressed, developmentally down-regulated 4
Reporter: lacZ
Direct Detection
Results
Specimen 1C: embryonic day 11.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS19: surface ectoderm Present 1C Authors report expression in skin.
TS19: neural tube marginal layer Present 1C Expression marginal layers of spinal cord.
TS19: future spinal cord Present Regionally restricted 1C Authors state that the majority of other spinal cord regions are devoid of expression, except for a small region around the central canal.

Specimen 1D: embryonic day 11.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS19: surface ectoderm Present 1D Expression in skin.
TS19: neural tube marginal layer Present 1D Expression in marginal layers of spinal cord.

Specimen 1E: embryonic day 11.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS19: future spinal cord Present Regionally restricted 1E No expression in ventral region of spinal cord.

Specimen E13.5 spinal cord not shown: embryonic day 13.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS21: spinal cord meninges Present Authors report that, at later stages (E13.5-E18.5), expression remained highly restricted to the surface of the spinal cord.

Specimen 1F: embryonic day 18.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS26: spinal cord Present Regionally restricted 1F Expression highly restricted to surface of spinal cord. Expression in small region just underneath the central canal. No expression in motoneurons in ventral spinal cord.
TS26: dorsal root ganglion Strong 1F
TS26: vertebral cartilage condensation Present 1F Expression in cartilage primordium of vertebra.

Specimen 1G: embryonic day 18.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS26: dorsal root ganglion Strong Regionally restricted 1G Expression in dorsal root ganglion, predominantly in Schwann cells or satellite cells.

Specimen 1H: embryonic day 18.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS26: spinal cord Present Regionally restricted 1H No expression in motoneurons in ventral spinal cord.

Specimen 1I: embryonic day 18.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS26: spinal cord meninges Present 1I Expression localized to meninges.

Specimen 1J: embryonic day 18.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS26: spinal cord Strong 1J No expression in motoneurons in ventral spinal cord.

Specimen 1K: embryonic day 18.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS26: diaphragm Strong 1K Intense expression in skeletal muscles.

Specimen 1L: embryonic day 18.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS26: limb muscle Strong 1L Intense expression in skeletal muscles.

Specimen S1A: embryonic day 13.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS21: diaphragm Present S1A Expression in skeletal muscles as early as E13.5.

Specimen S1B: embryonic day 15.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS23: diaphragm Present S1B Expression in skeletal muscles.

Specimen S1D: embryonic day 18.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS26: phrenic nerve Present Regionally restricted S1D Spotty expression in Schwann cells on surface of phrenic nerve.

Specimen E11.5 brain not shown: embryonic day 11.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS19: brain ventricular layer Present In the brain, expression primarily localized to meninges and ventricular zones.
TS19: primitive meninges Present In the brain, expression primarily localized to meninges and ventricular zones.

Specimen E13.5 brain not shown: embryonic day 13.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS21: brain meninges Present In the brain, expression primarily localized to meninges and ventricular zones.
TS21: brain ventricular layer Present In the brain, expression primarily localized to meninges and ventricular zones.

Specimen E16.5 brain not shown: embryonic day 16.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS24: brain meninges Present In the brain, expression primarily localized to meninges and ventricular zones.
TS24: brain ventricular layer Present In the brain, expression primarily localized to meninges and ventricular zones.

Specimen E18.5 brain not shown: embryonic day 18.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS26: brain meninges Present In the brain, expression primarily localized to meninges and ventricular zones.
TS26: brain ventricular layer Present In the brain, expression primarily localized to meninges and ventricular zones.

Specimen S2A: embryonic day 16.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS24: retina Present Widespread S2A Expression in cells across retina, especially in the ganglion cell layer.
TS24: extrinsic ocular muscle Present S2A Expression in extraocular muscle.
TS24: lens Strong S2A Intense expression in lens.

Specimen S2B: embryonic day 16.5; Nedd4Gt(OST16211)Lex/Nedd4+ (more )
Structure Level Pattern Image Note
TS24: brain ventricular layer Present Regionally restricted S2B Expression in brain primarily confined to ventricular zones.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory