Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Il4i1H46-b
Name:	interleukin 4 induced 1; histocompatibility 46, b variant
MGI ID:	MGI:6197069
Synonyms:	H46b
Gene:	Il4i1  Location: Chr7:44485712-44490233 bp, + strand  Genetic Position: Chr7, 28.93 cM
Alliance:	Il4i1H46-b page

Strain of Origin:

129/Sv

Allele Type:    Not Applicable (Not Applicable) Mutation:    Nucleotide substitutions   Mutation details: This minor histocompatibility antigen, initially identified as being between C57BL/10ScSn and 129/Rr but also found to be between C57BL/6J and 129P3/J, is caused by a single amino acid change at residue 25, which is alanine in C57BL/6J-derived H46-a and methionine for 129-derived H46-b. The 2 nucleotide sequence variations underlying this are G73A and C74T and the core antigenic peptide from each compete similarly for binding Ab. The core antigenic peptide in H46-b is HMFVEAIPELQ. (J:264442) Inheritance:    Semidominant

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il4i1 Mutation:	104 strains or lines available

Original:	J:10078 Roopenian DC, et al., Responses against antigens encoded by the H-3 histocompatibility locus: antigens stimulating class I MHC- and class II MHC-restricted T cells are encoded by separate genes. Immunogenetics. 1989;30(5):335-43
All:	2 reference(s)