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Gene Expression Data
Assay Details
Assay
Reference: J:171705 McNeill DS, et al., Development of melanopsin-based irradiance detecting circuitry. Neural Dev. 2011;6:8
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6192525
Gene symbol: Opn4
Gene name: opsin 4 (melanopsin)
Reporter: lacZ
Direct Detection
Results
Specimen 1F E14: embryonic day 14.0; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS22: neural retina Absent 1F E14 Authors report complete absence of expression at E14.

Specimen 1F E15: embryonic day 15.0; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS23: neural retina Present Regionally restricted 1F E15 Authors report expression begins at E15. Some expressing cells detected in ganglion cell layer; others appear to be migrating from neuroblast layer to ganglion cell layer.

Specimen 1G E15: embryonic day 15.0; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS23: neural retina Present Regionally restricted 1G E15 Authors report no expression in peripheral retina at E15.

Specimen 1G E16: embryonic day 16.0; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS24: neural retina Present Regionally restricted 1G E16 Subsequent expansion of the region of expressing cells.

Specimen 1G E18: embryonic day 18.0; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS26: neural retina Present Regionally restricted 1G E18 Subsequent expansion of the region of expressing cells.
TS26: optic nerve Absent 1G E18 No expression in central optic nerve.

Specimen 1G P0: postnatal day 0; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS27: neural retina Present Regionally restricted 1G P0 Authors report periphery is entirely filled in by P0.

Specimen 2C P0: postnatal day 0; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS27: suprachiasmatic nucleus Present Regionally restricted 2C P0 Expression in intrinsically photosensitive retinal ganglion cells (ipRGCs).

Specimen 2C P4: postnatal day 4; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS28: suprachiasmatic nucleus Present Regionally restricted 2C P4 Expression in intrinsically photosensitive retinal ganglion cells (ipRGCs).

Specimen 2C P7: postnatal day 7; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS28: suprachiasmatic nucleus Present Regionally restricted 2C P7 Expression in intrinsically photosensitive retinal ganglion cells (ipRGCs).

Specimen 2C P14: postnatal day 14; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS28: suprachiasmatic nucleus Present Regionally restricted 2C P14 Expression in intrinsically photosensitive retinal ganglion cells (ipRGCs).

Specimen 3 E17: embryonic day 17.0; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS25: suprachiasmatic nucleus Present Regionally restricted 3_E17 Expression in chiasm on ventral surface as early as E17.

Specimen 3 P1: postnatal day 1; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS27: suprachiasmatic nucleus Present Regionally restricted 3_P1 Serial sections from brains at different time points show spatial and termporal progression of intrinsically photosensitive retinal ganglion cell (ipRGC) innervation of the suprachiasmatic nucleus (SCN).

Specimen 3 P2: postnatal day 2; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS27: suprachiasmatic nucleus Present Regionally restricted 3_P2 Serial sections from brains at different time points show spatial and termporal progression of intrinsically photosensitive retinal ganglion cell (ipRGC) innervation of the suprachiasmatic nucleus (SCN).

Specimen 3 P3: postnatal day 3; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS27: suprachiasmatic nucleus Present Regionally restricted 3_P3 Serial sections from brains at different time points show spatial and termporal progression of intrinsically photosensitive retinal ganglion cell (ipRGC) innervation of the suprachiasmatic nucleus (SCN).

Specimen 3 P4: postnatal day 4; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS28: suprachiasmatic nucleus Present Regionally restricted 3_P4 Serial sections from brains at different time points show spatial and termporal progression of intrinsically photosensitive retinal ganglion cell (ipRGC) innervation of the suprachiasmatic nucleus (SCN).

Specimen 3 P6: postnatal day 6; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS28: suprachiasmatic nucleus Present Regionally restricted 3_P6 Serial sections from brains at different time points show spatial and termporal progression of intrinsically photosensitive retinal ganglion cell (ipRGC) innervation of the suprachiasmatic nucleus (SCN).

Specimen 3 P14: postnatal day 14; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS28: suprachiasmatic nucleus Present Regionally restricted 3_P14 Serial sections from brains at different time points show spatial and termporal progression of intrinsically photosensitive retinal ganglion cell (ipRGC) innervation of the suprachiasmatic nucleus (SCN).

Specimen 3 P21: postnatal day 21; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS28: suprachiasmatic nucleus Present Regionally restricted 3_P21 Serial sections from brains at different time points show spatial and termporal progression of intrinsically photosensitive retinal ganglion cell (ipRGC) innervation of the suprachiasmatic nucleus (SCN).

Specimen 3 P49: postnatal day 49; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS28: suprachiasmatic nucleus Present Regionally restricted 3_P49 Serial sections from brains at different time points show spatial and termporal progression of intrinsically photosensitive retinal ganglion cell (ipRGC) innervation of the suprachiasmatic nucleus (SCN).

Specimen 4C P0: postnatal day 0; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS27: pretectum Absent 4C P0 No expression in olivary pretectal nucleus.

Specimen 4C P7: postnatal day 7; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS28: olivary pretectal nucleus Weak Regionally restricted 4C P7 Faint expression in shell starting at P7.

Specimen 4C P10: postnatal day 10; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS28: olivary pretectal nucleus Present 4C P10

Specimen 4C P14: postnatal day 14; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS28: olivary pretectal nucleus Present Regionally restricted 4C P14 Authors report adult-like innervation by P14.

Specimen 5 P0: postnatal day 0; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS27: dorsal lateral geniculate nucleus Present Regionally restricted 5_(upper) P0 Authors report expression in axons throughout lateral geniculate nucleus from birth.
TS27: ventral lateral geniculate nucleus Present Regionally restricted 5_(upper) P0 Authors report expression in axons throughout lateral geniculate nucleus from birth.

Specimen 5 P4: postnatal day 4; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS28: dorsal lateral geniculate nucleus Present Regionally restricted 5_(upper) P4 Authors report expression in axons throughout lateral geniculate nucleus from birth.
TS28: ventral lateral geniculate nucleus Present Regionally restricted 5_(upper) P4 Authors report expression in axons throughout lateral geniculate nucleus from birth.

Specimen 5 P7: postnatal day 7; Opn4tm1Yau/Opn4+ (more )
Structure Level Pattern Image Note
TS28: dorsal lateral geniculate nucleus Present Regionally restricted 5_(upper) P7 Authors report expression in axons throughout lateral geniculate nucleus from birth.
TS28: ventral lateral geniculate nucleus Present Regionally restricted 5_(upper) P7 Authors report expression in axons throughout lateral geniculate nucleus from birth.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory