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Gene Expression Data
Assay Details
Assay
Reference: J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6188909
Gene symbol: Sox6
Gene name: SRY (sex determining region Y)-box 6
Antibody: anti-Sox6 (guinea pig)
Detection system: Secondary antibody
Assay notes: The authors used two antibodies to Sox6 but did not distinguish which data was derived from which; it is possible MGI:6159133 was used to obtain some or all of these data.
Results
Specimen 2D - SOX2/10: embryonic day 15.5 (more )
Note: Double labeled: red - Sox6; blue - Sox10 or Sox2 (to label enteric progenitors).
Structure Level Pattern Image Note
TS23: enteric nervous system Present 2D SOX6 upper Double staining shows co-expression in progenitors.
Specimen 2D - HUD/D: embryonic day 15.5 (more )
Note: Double labeled: red - Sox6; green - Elavl3/4 (to label neurons).
Structure Level Pattern Image Note
TS23: enteric nervous system Present 2D SOX6 lower Double staining shows co-expression in neurons.
Specimen Table 3B: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: enteric nervous system Present Co-expression analysis was done with neurotransmitters and neuropeptides: TH, CGRP, Calb1, Nos1, NPY, 5-HT and VIP (in the stomach). Partial co-expression was seen with with TH, Calb1, and NPY and no co-expression with the rest.
Specimen 3C: embryonic day 18.5 (more )
Note: Double labeled: red - Sox6; green - Th (assay MGI:6188917).
Structure Level Pattern Image Note
TS26: enteric nervous system Present 3C SOX6 Co-expression with tyrosine hydroxylase (Th) was observed in the stomach.
Specimen 4A stomach - E11.5: embryonic day 11.5 (more )
Note: Triple labeled: red - Sox6; green - Elavl3/4 (to label neurons); blue - Sox10 (to label enteric progenitors).
Structure Level Pattern Image Note
TS19: enteric nervous system Present 4A stomach - E11.5 Expression was seen in a few progenitors.
Specimen 4A stomach - E16.5: embryonic day 16.5 (more )
Note: Triple labeled: red - Sox6; green - Elavl3/4 (to label neurons); blue - Sox10 (to label enteric progenitors).
Structure Level Pattern Image Note
TS24: enteric nervous system Present 4A stomach - E16.5 Expression was seen in a few progenitors and neurons.
Specimen 4A stomach - E18.5: embryonic day 18.5 (more )
Note: Triple labeled: red - Sox6; green - Elavl3/4 (to label neurons); blue - Sox10 (to label enteric progenitors).
Structure Level Pattern Image Note
TS26: enteric nervous system Present 4A stomach - E18.5 Expression was seen in a few neurons and progenitors.
Specimen 4A intestine - E11.5: embryonic day 11.5 (more )
Note: Triple labeled: red - Sox6; green - Elavl3/4 (to label neurons); blue - Sox10 (to label enteric progenitors).
Structure Level Pattern Image Note
TS19: enteric nervous system Absent 4A intestine - E11.5
Specimen 4A intestine - E16.5: embryonic day 16.5 (more )
Note: Triple labeled: red - Sox6; green - Elavl3/4 (to label neurons); blue - Sox10 (to label enteric progenitors).
Structure Level Pattern Image Note
TS24: enteric nervous system Absent 4A intestine - E16.5
Specimen 4A intestine - E18.5: embryonic day 18.5 (more )
Note: Triple labeled: red - Sox6; green - Elavl3/4 (to label neurons); blue - Sox10 (to label enteric progenitors).
Structure Level Pattern Image Note
TS26: enteric nervous system Absent 4A intestine - E18.5
Specimen 4B TH: embryonic day 18.5 (more )
Note: Double labeled: red - Sox6; green - Th (assay MGI:6188917).
Structure Level Pattern Image Note
TS26: enteric nervous system Present 4B TH Double staining shows co-expression with Th.
Specimen 4B NPY: embryonic day 18.5 (more )
Note: Double labeled: red - Sox6; green - Npy (assay MGI:6189075).
Structure Level Pattern Image Note
TS26: enteric nervous system Present 4B NPY Double staining shows co-expression with NPY.
Specimen 4B CALB1: embryonic day 18.5 (more )
Note: Double labeled: red - Sox6; green - Calb1 (assay MGI:6189071).
Structure Level Pattern Image Note
TS26: enteric nervous system Present 4B CALB1 Double staining shows co-expression with calbindin.
Specimen 4C NOS: embryonic day 18.5 (more )
Note: Double labeled: red - Sox6; green - Nos1 (assay MGI:6189072).
Structure Level Pattern Image Note
TS26: enteric nervous system Present 4C NOS Double staining shows no co-expression with Nos1.
Specimen 4C VIP: embryonic day 18.5 (more )
Note: Double labeled: red - Sox6; green - Vip (assay MGI:6189079).
Structure Level Pattern Image Note
TS26: enteric nervous system Present 4C VIP Double staining shows no co-expression with VIP.
Specimen 4E: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: enteric nervous system Present 4E
TS26: gut mucosa Present 4E
TS26: gut serosa Present 4E
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory