Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Card14em9Lutzy
Name:	caspase recruitment domain family, member 14; endonuclease-mediated mutation 9, Cathy Lutz
MGI ID:	MGI:6164625
Synonyms:	Card14deltaE138
Gene:	Card14  Location: Chr11:119198594-119236201 bp, + strand  Genetic Position: Chr11, 83.36 cM
Alliance:	Card14em9Lutzy page

Strain of Origin:

C57BL/6J

Allele Type:    Endonuclease-mediated (Humanized sequence) Mutation:    Intragenic deletion   Mutation details: CRISPR/cas9 endonuclease mediated genome editing was used to introduce a deletion of a GAG codon from exon 6 that results in the deletion of the glutamic acid (E) at position 138. Card14em5Lutzy and Card14em9Lutzy were generated from two different founders, both carry the same mutation. (J:262723)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Card14 Mutation:	38 strains or lines available

Original:	J:262723 Mellett M, et al., CARD14 gain-of-function mutation alone is sufficient to drive IL-23/IL-17-mediated psoriasiform skin inflammation in vivo. J Invest Dermatol. 2018 Apr 21;
All:	3 reference(s)