Ampd1tm1Tm
Targeted Allele Detail
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| Symbol: |
Ampd1tm1Tm |
| Name: |
adenosine monophosphate deaminase 1; targeted mutation 1, Takayuki Morisaki |
| MGI ID: |
MGI:6157956 |
| Synonyms: |
A1(-) |
| Gene: |
Ampd1 Location: Chr3:102981330-103007036 bp, + strand Genetic Position: Chr3, 45.25 cM
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| Alliance: |
Ampd1tm1Tm page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:260685
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| Parent Cell Line: |
D3 (ES Cell)
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| Strain of Origin: |
129S2/SvPas
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Insertion
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Mutation details: A neomycin selection cassette was inserted into exon 6. Gene disruption was confirmed by PCR and Southern blotting. Northern and western blots confirmed that homozygous mutant mice did not show any expression of the enoded RNA or protein. AMPD enzyme activity was almost undetectable in the gastrocnemius and extensor digitorum longus while ~10% of AMPD activity remained in the soleus muscle. Histochemical staining confirmed loss of enzyme activity in all muscle types from homozygous mutant mice.
(J:260685)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ampd1 Mutation: |
49 strains or lines available
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| Original: |
J:260685 Cheng J, et al., Effect of isolated AMP deaminase deficiency on skeletal muscle function. Mol Genet Metab Rep. 2014;1:51-59 |
| All: |
3 reference(s) |
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Analysis Tools
