Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Ogg1m1
Name:	8-oxoguanine DNA-glycosylase 1; mutation 1
MGI ID:	MGI:6157073
Synonyms:	OGG1-R336H
Gene:	Ogg1  Location: Chr6:113303959-113311149 bp, + strand  Genetic Position: Chr6, 52.75 cM, cytoband E-F1
Alliance:	Ogg1m1 page

Strain of Origin:

various

Allele Type:    Spontaneous (Not Applicable) Mutation:    Single point mutation   Mutation details: A G-to-A change at the fifty-ninth nucleotide in exon 7 resulted in a substitution of arginine with histidine at position 336 (p.R336H) in a putative nuclear localization signal. The mutation led to disruption of the nuclear localization of the enzyme, although the activity remained normal. (J:59724)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ogg1 Mutation:	23 strains or lines available

Original:	J:59724 Choi JY, et al., Thermolabile 8-hydroxyguanine DNA glycosylase with low activity in senescence-accelerated mice due to a single-base mutation. Free Radic Biol Med. 1999 Oct;27(7-8):848-54
All:	2 reference(s)