Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	H2-Ab1g7-em1Mvw
Name:	histocompatibility 2, class II antigen A, beta 1; endonuclease-mediated mutation 1, Michael Wiles
MGI ID:	MGI:6156109
Synonyms:	H2-Ab1em1Mvw, IAnull
Gene:	H2-Ab1  Location: Chr17:34482201-34488392 bp, + strand  Genetic Position: Chr17, 17.98 cM
Alliance:	H2-Ab1g7-em1Mvw page

Strain of Origin:

NOD.Cg-Prkdcscid H2-K1b-tm1Bpe H2-D1b-tm1Bpe Il2rgtm1Wjl/Sz

Allele Type:    Endonuclease-mediated (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: This TALEN-mediated null mutation has a 61 bp deletion in exon 2, Chr 17: :34264928-34264988 (GRCm38), followed by 39 bp of retained endogenous sequence, then a 507 bp deletion, Chr 17: 34265028-34265534, with a 7 bp insertion (CCGTCAC) in its place, the impact of which is a disruption of most of exon 2. Flow cytometric analysis confirmed this to be a null allele. (J:268035) Inheritance:    Not Specified

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any H2-Ab1 Mutation:	81 strains or lines available

Original:	J:268035 Brehm MA, et al., Lack of acute xenogeneic graft- versus-host disease, but retention of T-cell function following engraftment of human peripheral blood mononuclear cells in NSG mice deficient in MHC class I and II expression. FASEB J. 2018 Nov 1;:fj201800636R
All:	2 reference(s)