Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tcea3tm1Skmz
Name:	transcription elongation factor A (SII), 3; targeted mutation 1, Kazuhisa Sekimizu
MGI ID:	MGI:6144038
Synonyms:	SII-K1-
Gene:	Tcea3  Location: Chr4:135975253-136002214 bp, + strand  Genetic Position: Chr4, 68.34 cM, cytoband D3
Alliance:	Tcea3tm1Skmz page

Germline Transmission:	Earliest citation of germline transmission: J:258002
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A polII-neomycin selection cassette replaced exon 1, which contains the initiation codon, and part of the 5' sequence of exon 2. Northern blot analysis confirmed the complete loss of mRNA transcript in the heart, kidney, liver, and skeletal muscle of adult homozygous mutant mice. (J:258002)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tcea3 Mutation:	46 strains or lines available

Original:	J:258002 Tano K, et al., Reduced expression of Sytl 1 and Ccdc21 and impaired induction of Mt I by oxidative stress in SII-K1 knockout mice. Drug Discov Ther. 2010 Oct;4(5):368-72
All:	1 reference(s)