Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Symbol:	Nr1h4tm1.2Gonz
Name:	nuclear receptor subfamily 1, group H, member 4; targeted mutation 1.2, Frank Gonzalez
MGI ID:	MGI:6121372
Synonyms:	Fxrfl
Gene:	Nr1h4  Location: Chr10:89290096-89369447 bp, - strand  Genetic Position: Chr10, 44.98 cM
Alliance:	Nr1h4tm1.2Gonz page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The targeting construct contains a loxP site inserted in the intron 5' to the last exon and a loxP-flanked neomycin cassette inserted 3' to the last exon. Germline Cre-mediated recombination removed the floxed neo cassette leaving the last exon floxed. The last exon encodes the ligand binding domain and all of the 3' untranslated region. (J:64792)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr1h4 Mutation:	43 strains or lines available

Original:	J:64792 Sinal CJ, et al., Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell. 2000 Sep 15;102(6):731-44
All:	7 reference(s)