Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hacd1tm1Akih
Name:	3-hydroxyacyl-CoA dehydratase 1; targeted mutation 1, Akio Kihara
MGI ID:	MGI:6118922
Gene:	Hacd1  Location: Chr2:14031642-14060846 bp, - strand  Genetic Position: Chr2, 10.3 cM, cytoband A2
Alliance:	Hacd1tm1Akih page

Germline Transmission:	Earliest citation of germline transmission: J:247117
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Using recombineering techniques, exon 6, coding for an active site, was replaced with a loxP site flanked neomycin resistance gene cassette. (J:247117)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hacd1 Mutation:	16 strains or lines available

Original:	J:247117 Sawai M, et al., The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways. J Biol Chem. 2017 Sep 15;292(37):15538-15551
All:	1 reference(s)