Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(H2-Ea-HLA-DRB1*0401*)1Dv
Name:	transgene insertion 1, Chella David
MGI ID:	MGI:6117040
Synonyms:	DR4beta(NT)
Transgene:	Tg(H2-Ea-HLA-DRB1*0401*)1Dv  Location: unknown
Alliance:	Tg(H2-Ea-HLA-DRB1*0401*)1Dv page

Strain of Origin:

(SWR x C57BL/10)F1

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Mutation details: This transgene has the mouse H2-Ealpha promoter (and rabbit beta-globin intron) upstream of a human HLA-DRB1*0401 cDNA sequence engineered to have amino acid mutations (Q110N and K139T) in the beta2 domain to provide an improved interaction with murine CD4. (J:134781)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available

Original:	J:134781 Pan S, et al., HLA-DR4 (DRB1*0401) transgenic mice expressing an altered CD4-binding site: specificity and magnitude of DR4-restricted T cell response. J Immunol. 1998 Sep 15;161(6):2925-9
All:	2 reference(s)