Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Mc4rtm2.2Lowl
Name:	melanocortin 4 receptor; targeted mutation 2.2, Bradford B Lowell
MGI ID:	MGI:5824370
Gene:	Mc4r  Location: Chr18:66990776-66993558 bp, - strand  Genetic Position: Chr18, 39.72 cM, cytoband E1
Alliance:	Mc4rtm2.2Lowl page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	W4 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: One loxP site was inserted in the 5'UTR and a second loxP site followed by a FRT-flanked kanamycin resistance cassette was inserted in the 3'UTR. The single coding exon is thus flanked by loxP sites. Flp-mediated recombination removed the FRT-flanked kanamycin cassette. (J:193452)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mc4r Mutation:	44 strains or lines available

Original:	J:193452 Sohn JW, et al., Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons. Cell. 2013 Jan 31;152(3):612-9
All:	4 reference(s)