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Gene Expression Data
Assay Details
Assay
Reference: J:206322 Kwon TJ, et al., Methionine sulfoxide reductase B3 deficiency causes hearing loss due to stereocilia degeneration and apoptotic cell death in cochlear hair cells. Hum Mol Genet. 2014 Mar 15;23(6):1591-601
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5818286
Gene symbol: Msrb3
Gene name: methionine sulfoxide reductase B3
Antibody: anti-MsrB3
Detection system: Secondary antibody coupled to Alexa Fluor 555
Results
Specimen 3A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cochlear duct Absent 3A
TS20: saccule Absent 3A
TS20: utricle Absent 3A
Specimen 3B: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: cochlear duct Absent 3B
Specimen 3C: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cochlear duct Absent 3C
Specimen 3D: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: cochlear duct Present Regionally restricted 3D Expressed primarily in the basal and middle turns, and later in all cochlear turns.
Specimen 3E: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: cochlear duct epithelium Present 3E
Specimen 3F: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cochlea epithelium Present 3F
Specimen 3G/H: postnatal day 18 (more )
Structure Level Pattern Image Note
TS28: cochlea epithelium Present 3G , 3H Expressed in the cochlear epithelium from the inner to the outer sulcus cells, encompassing the auditory hair cells.
Specimen 3I: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cochlear duct Absent 3I
TS20: endolymphatic appendage Absent 3I
TS20: saccule Absent 3I
TS20: utricle Absent 3I
Specimen 3J: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: saccule epithelium Present 3J
TS21: utricle epithelium Present 3J
TS21: vestibular component epithelium Present Regionally restricted 3J Expressed in crista amullaris.
Specimen 3K: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: vestibular component epithelium Present 3K
Specimen 3L: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: vestibular component epithelium Present 3L
Specimen 3M: embryonic day 18.5 (more )
Structure Level Pattern Image Note
TS26: vestibular component epithelium Present 3M
Specimen 3N: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: vestibular epithelium Present 3N
Specimen 30: postnatal day 18 (more )
Structure Level Pattern Image Note
TS28: vestibular epithelium Present 3O
Specimen 4A: postnatal (more )
Note: Double labeled: red - Msrb3; green - Phalloidin.
Structure Level Pattern Image Note
TS28: organ of Corti Present Regionally restricted 4A Expressed in the base of the stereocilia in both inner hair cells and outer hair cells.
Specimen 4B/C: postnatal (more )
Note: Double labeled: red - Msrb3; green - Phalloidin.
Structure Level Pattern Image Note
TS28: organ of Corti Strong Regionally restricted 4C , 4B Densely localized at the base of the stereocilia and scattered as spots throughout the entire cell body.
Specimen 4D: postnatal (more )
Note: Double labeled: red - Msrb3; green - Phalloidin.
Structure Level Pattern Image Note
TS28: organ of Corti Present Regionally restricted 4D Expressed in the base of the stereocilia in outer hair cells.
Specimen S3A: postnatal day 18 (more )
Note: Double labeled: red - Msrb3; green - Myo7a (assay MGI:5818546).
Structure Level Pattern Image Note
TS28: organ of Corti Present Regionally restricted S3A left , S3A merge Expressed in sensory epithelial cells.
Specimen S3B: postnatal day 18 (more )
Note: Double labeled: red - Msrb3; green - Myo7a (assay MGI:5818546).
Structure Level Pattern Image Note
TS28: saccule epithelium Present S3B merge , S3B left Expressed in sensory epithelial cells.
Specimen S3C: postnatal day 18 (more )
Note: Double labeled: red - Msrb3; green - Myo7a (assay MGI:5818546).
Structure Level Pattern Image Note
TS28: utricle epithelium Present S3C left , S3C merge Expressed in sensory epithelial cells.
Specimen S3D: postnatal day 18 (more )
Note: Double labeled: red - Msrb3; green - Myo7a (assay MGI:5818546).
Structure Level Pattern Image Note
TS28: crista ampullaris Present Regionally restricted S3D left , S3D merge Expressed in sensory epithelial cells.
Specimen S4A upper: postnatal day 20; Msrb3tm1Hyk/Msrb3+ (more )
Note: Double labeled: red - Msrb3; green - Phalloidin.
Structure Level Pattern Image Note
TS28: organ of Corti Present S4A upper Expressed in the stereocilia of hair cells, similar to those of wild-type.
Specimen S4A lower: postnatal day 20; Msrb3tm1Hyk/Msrb3tm1Hyk (more )
Note: Double labeled: red - Msrb3; green - Phalloidin.
Structure Level Pattern Image Note
TS28: organ of Corti Absent S4A lower
Specimen S4B upper: postnatal day 20; Msrb3tm1Hyk/Msrb3+ (more )
Note: Double labeled: red - Msrb3; green - Phalloidin.
Structure Level Pattern Image Note
TS28: organ of Corti Weak Scattered S4B upper Expressed in the cell body of the hair cells.
Specimen S4B lower: postnatal day 20; Msrb3tm1Hyk/Msrb3tm1Hyk (more )
Note: Double labeled: red - Msrb3; green - Phalloidin.
Structure Level Pattern Image Note
TS28: organ of Corti Absent S4B lower
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
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