Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Lrrk2tm3.1Arte
Name:	leucine-rich repeat kinase 2; targeted mutation 3.1, TaconicArtemis
MGI ID:	MGI:5811334
Synonyms:	LRRK2[S910A+S935A]
Gene:	Lrrk2  Location: Chr15:91557378-91700323 bp, + strand  Genetic Position: Chr15, 46.07 cM, cytoband F1
Alliance:	Lrrk2tm3.1Arte page

Germline Transmission:	Earliest citation of germline transmission: J:237182
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A targeting vector containing an FRT-flanked PuroR selection cassette was used to insert S910A and S935A point mutations into exon 21. Flp-mediated recombination removed the FRT-flanked PuroR cassette. (J:237182)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lrrk2 Mutation:	156 strains or lines available

Original:	J:237182 Ito G, et al., Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. Biochem J. 2016 Sep 01;473(17):2671-85
All:	2 reference(s)