Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Grin2atm1.1Jpleo
Name:	glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1.1, John P Leonard
MGI ID:	MGI:5811328
Synonyms:	deltaPKC, Grin2adeltaPKC
Gene:	Grin2a  Location: Chr16:9385762-9813424 bp, - strand  Genetic Position: Chr16, 5.28 cM
Alliance:	Grin2atm1.1Jpleo page

Germline Transmission:	Earliest citation of germline transmission: J:235504
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A targeting vector containing mutations that result in amino acid substitutions S1991A, Y1292F, S1312A and Y1472F, and a loxP site flanked NEO cassette was used to disrupt exon 12. Cre-mediated recombination removed the floxed neo cassette. (J:235504)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grin2a Mutation:	66 strains or lines available

Original:	J:235504 Balu D, et al., Behavioral and physiological characterization of PKC-dependent phosphorylation in the Grin2aPKC mouse. Brain Res. 2016 Sep 1;1646:315-26
All:	1 reference(s)