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Gene Expression Data
Assay Details
Assay
Reference: J:107696 Kanzler B, et al., Hox11 acts cell autonomously in spleen development and its absence results in altered cell fate of mesenchymal spleen precursors. Dev Biol. 2001 Jun 1;234(1):231-43
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:5807192
Gene symbol: Tlx1
Gene name: T cell leukemia, homeobox 1
Reporter: lacZ
Direct Detection
Assay notes: Fixative was 4% formaldehyde, 0.8% glutaraldehyde.
Results
Specimen 1 +/- dE11.5: embryonic day 11.5; Tlx1tm1Thr/Tlx1+ (more )
Structure Level Pattern Image Note
TS19: dorsal mesogastrium Present 1_Hox11+/- dE11.5
TS19: pancreas primordium Present 1_Hox11+/- dE11.5

Specimen 1 -/- dE11.5: embryonic day 11.5; Tlx1tm1Thr/Tlx1tm1Thr (more )
Structure Level Pattern Image Note
TS19: dorsal mesogastrium Present 1_Hox11-/- dE11.5
TS19: pancreas primordium Present 1_Hox11-/- dE11.5

Specimen 1 +/- dE12.5: embryonic day 12.5; Tlx1tm1Thr/Tlx1+ (more )
Structure Level Pattern Image Note
TS20: pancreas Present 1_Hox11+/- dE12.5
TS20: dorsal mesogastrium Present Regionally restricted 1_Hox11+/- dE12.5 Expression is in the spleen anlage.

Specimen 1 -/- dE12.5: embryonic day 12.5; Tlx1tm1Thr/Tlx1tm1Thr (more )
Structure Level Pattern Image Note
TS20: pancreas Present 1_Hox11-/- dE12.5
TS20: dorsal mesogastrium Present Regionally restricted 1_Hox11-/- dE12.5 Expression is in the spleen anlage.

Specimen 1 +/- dE13: embryonic day 13.0; Tlx1tm1Thr/Tlx1+ (more )
Structure Level Pattern Image Note
TS21: pancreas Present 1_Hox11+/- dE13
TS21: dorsal mesogastrium Present Regionally restricted 1_Hox11+/- dE13 Expression is in the spleen anlage.

Specimen 1 -/- dE13: embryonic day 13.0; Tlx1tm1Thr/Tlx1tm1Thr (more )
Structure Level Pattern Image Note
TS21: pancreas Present 1_Hox11-/- dE13
TS21: dorsal mesogastrium Present Regionally restricted 1_Hox11-/- dE13 Expression is in the spleen anlage.

Specimen 1 +/- dE13.5: embryonic day 13.5; Tlx1tm1Thr/Tlx1+ (more )
Structure Level Pattern Image Note
TS21: dorsal mesogastrium Present 1_Hox11+/- dE13.5
TS21: pancreas Present 1_Hox11+/- dE13.5

Specimen 1 -/- dE13.5: embryonic day 13.5; Tlx1tm1Thr/Tlx1tm1Thr (more )
Structure Level Pattern Image Note
TS21: pancreas Present 1_Hox11-/- dE13.5
TS21: abdominal segment of trunk Present Regionally restricted 1_Hox11-/- dE13.5 Expression is in rudimentary tissue residing between the stomach and pancreas.

Specimen 1 +/- dE15.5: embryonic day 15.5; Tlx1tm1Thr/Tlx1+ (more )
Structure Level Pattern Image Note
TS23: pancreas Present 1_Hox11+/- dE15.5
TS23: spleen primordium Present 1_Hox11+/- dE15.5

Specimen 1 -/- dE15.5: embryonic day 15.5; Tlx1tm1Thr/Tlx1tm1Thr (more )
Structure Level Pattern Image Note
TS23: pancreas Present 1_Hox11-/- dE15.5
TS23: abdominal segment of trunk Present Regionally restricted 1_Hox11-/- dE15.5 Expression is in rudimentary tissue residing between the stomach and pancreas.

Specimen 1 +/- dE17.5: embryonic day 17.5; Tlx1tm1Thr/Tlx1+ (more )
Structure Level Pattern Image Note
TS25: pancreas Present 1_Hox11+/- dE17.5
TS25: spleen Present 1_Hox11+/- dE17.5

Specimen 1 -/- dE17.5: embryonic day 17.5; Tlx1tm1Thr/Tlx1tm1Thr (more )
Structure Level Pattern Image Note
TS25: pancreas Present 1_Hox11-/- dE17.5
TS25: splenic artery Present 1_Hox11-/- dE17.5
TS25: abdominal segment of trunk Present Regionally restricted 1_Hox11-/- dE17.5 Expression is in rudimentary tissue residing between the stomach and pancreas.
TS25: venous blood vessel Present Regionally restricted 1_Hox11-/- dE17.5 Expression is in the splenic vein.

Specimen 3 dE15 +/-: embryonic day 15.0; Tlx1tm1Thr/Tlx1+ (more )
Structure Level Pattern Image Note
TS23: spleen primordium Present 3_dE15 +/-

Specimen 3 dE15-15.5 +/-: embryonic day 15.0-15.5; Tlx1tm1Thr/Tlx1+ (more )
Structure Level Pattern Image Note
TS23: spleen primordium Present 3_dE15-15.5 +/-

Specimen 3 dE15-15.5 +/- right: embryonic day 15.0-15.5; Tlx1tm1Thr/Tlx1+ (more )
Structure Level Pattern Image Note
TS23: spleen primordium Present 3_dE15-15.5 +/- right

Specimen 3 dE15.5 +/-: embryonic day 15.5; Tlx1tm1Thr/Tlx1+ (more )
Structure Level Pattern Image Note
TS23: spleen primordium Present 3_dE15.5 +/-

Specimen 3 dE15.5 -/-: embryonic day 15.5; Tlx1tm1Thr/Tlx1tm1Thr (more )
Structure Level Pattern Image Note
TS23: spleen primordium Present 3_dE15.5-/-

Specimen 4A: postnatal day 5; Tlx1tm1Thr/Tlx1tm1Thr (more )
Structure Level Pattern Image Note
TS28: splenic artery Present 4A
TS28: vein Present Regionally restricted 4A Expression is in the splenic vein.

Specimen 4B: postnatal day 28; Tlx1tm1Thr/Tlx1tm1Thr (more )
Structure Level Pattern Image Note
TS28: splenic artery Absent 4B
TS28: vein Absent 4B Absent in the splenic vein.

Specimen 4C: postnatal day 28; Tlx1tm1Thr/Tlx1+ (more )
Structure Level Pattern Image Note
TS28: pancreas Present 4C
TS28: splenic artery Absent 4C
TS28: vein Absent 4C Absent in the splenic vein.

Specimen 4D: postnatal day 5; Tlx1tm1Thr/Tlx1tm1Thr (more )
Structure Level Pattern Image Note
TS28: spleen Present 4D
TS28: artery tunica adventitia Present Regionally restricted 4D , 4H , 4F Expression is in the tunica adventitia of the splenic artery.
TS28: splenic artery Present Regionally restricted 4D , 4H , 4F Expression is in the tunica adventitia of the splenic artery.
TS28: vein tunica adventitia Weak Regionally restricted 4D , 4F , 4H Expression is in the tunica adventitia of the splenic vein.
TS28: pancreas Weak 4G , 4D

Specimen 4E: postnatal day 5; Tlx1tm1Thr/Tlx1+ (more )
Structure Level Pattern Image Note
TS28: pancreas Weak 4E

Specimen 5A: postnatal adult; Tlx1tm1Thr/Tlx1+ (more )
Structure Level Pattern Image Note
TS28: spleen Present 5A

Specimen 5B: postnatal adult; Tlx1tm1Thr/Tlx1+ (more )
Note: (C) is a higher magnification of (B).
Structure Level Pattern Image Note
TS28: spleen capsule Present 5B , 5C
TS28: spleen trabeculum Present 5B , 5C

Specimen not shown: postnatal week 6; Tlx1tm1Thr/Tlx1+ (more )
Structure Level Pattern Image Note
TS28: pancreas Absent


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory