Tg(Col1a2-KLF6*)1Fdmn
Transgene Detail
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Symbol: |
Tg(Col1a2-KLF6*)1Fdmn |
Name: |
transgene insertion 1, Scott Friedman |
MGI ID: |
MGI:5796480 |
Synonyms: |
Colalpha2(I)-KLF6-SV1 |
Transgene: |
Tg(Col1a2-KLF6*)1Fdmn Location: unknown
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Alliance: |
Tg(Col1a2-KLF6*)1Fdmn page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Col1a2-KLF6*)1Fdmn expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
KLF6 (1316) |
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splice variant 1 |
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Mutation details: The transgene was designed with a mutant human KLF6 gene driven by the collagen, type I, alpha 2 (Col1a2) promoter. The KLF6 alternative splice isoform - splice variant 1 (SV1) - lacks the DNA binding domain.
(J:235492)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:235492 Ghiassi-Nejad Z, et al., Reduced hepatic stellate cell expression of Kruppel-like factor 6 tumor suppressor isoforms amplifies fibrosis during acute and chronic rodent liver injury. Hepatology. 2013 Feb;57(2):786-96 |
All: |
1 reference(s) |
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