Summary | Transgene origin | Transgene description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tg(Prnp-PFN1)34Zxu
Name:	transgene insertion 34, Zuoshang Xu
MGI ID:	MGI:5796265
Synonyms:	Prp-PFN1WT
Transgene:	Tg(Prnp-PFN1)34Zxu  Location: unknown
Alliance:	Tg(Prnp-PFN1)34Zxu page

Strain of Origin:

FVB/NJ

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Tg(Prnp-PFN1)34Zxu expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human PFN1 (5216) Pfn1  (MGI:97549)   Mutation details: The transgenic construct contains a human profilin 1 cDNA sequence with a V5 tag (45 bp) fused to the N-terminus and inserted between exon 2 and exon 3 of mouse prion protein gene at a unique XhoI site in the MoPrP.Xho plasmid vector. Founder line 34 was found to have stable high expression predominantly in the central nervous system. (J:235427)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:235427 Yang C, et al., Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6209-E6218
All:	1 reference(s)