Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aknatm1Mak
Name:	AT-hook transcription factor; targeted mutation 1, Tak Mak
MGI ID:	MGI:5788727
Synonyms:	AKNA KO
Gene:	Akna  Location: Chr4:63285362-63321591 bp, - strand  Genetic Position: Chr4, 33.96 cM
Alliance:	Aknatm1Mak page

Germline Transmission:	Earliest citation of germline transmission: J:233952
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Hypomorph) Mutation:    Intragenic deletion   Mutation details: The targeting vector uses a PGK-neo cassette to disrupt exons 19 through 21. qRT-PCR analysis indicates that transcript expression is reduced but not completely abolished. (J:233952)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Akna Mutation:	49 strains or lines available

Original:	J:233952 Ma W, et al., Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice. Cell Res. 2011 Nov;21(11):1564-77
All:	1 reference(s)