Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Nfkb2tm1Ukl
Name:	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; targeted mutation 1, Ulf Klein
MGI ID:	MGI:5788158
Synonyms:	nfkb2fl
Gene:	Nfkb2  Location: Chr19:46292759-46300824 bp, + strand  Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
Alliance:	Nfkb2tm1Ukl page

Germline Transmission:	Earliest citation of germline transmission: J:233743
Parent Cell Line:	KV1 (ES Cell)
Strain of Origin:	(C57BL/6J x 129S6/SvEvTac)F1

Allele Type:    Targeted (Conditional ready, No functional change, Reporter) Mutation:    Insertion   Mutation details: Sequence encoding a promoterless eGFP minigene, a loxP site and the PGKneo cassette is inserted upstream of exon 1 of the targeted gene, and another loxP site followed by the PGK promoter is inserted downstream of exon 2. The translation start site is in exon 2. The entire targeted region is flanked by FRT sites. Recombination using Cre recombinase will remove the exons while allowing EGFP expression or FLP-mediated recombination will remove both the exons and the EGFP. (J:233743)

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nfkb2 Mutation:	49 strains or lines available

Original:	J:233743 De Silva NS, et al., Impairment of Mature B Cell Maintenance upon Combined Deletion of the Alternative NF-kappaB Transcription Factors RELB and NF-kappaB2 in B Cells. J Immunol. 2016 Mar 15;196(6):2591-601
All:	5 reference(s)