Tg(Camk2a-Grin2a/Grin2b)1Jzt
Transgene Detail
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| Symbol: |
Tg(Camk2a-Grin2a/Grin2b)1Jzt |
| Name: |
transgene insertion 1, Joe Z Tsien |
| MGI ID: |
MGI:5780173 |
| Synonyms: |
GluN2A2B(CT), Tg-GluN2A2B(CTR), Tg-NR2A2B(CT) |
| Transgene: |
Tg(Camk2a-Grin2a/Grin2b)1Jzt Location: unknown
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| Alliance: |
Tg(Camk2a-Grin2a/Grin2b)1Jzt page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Camk2a-Grin2a/Grin2b)1Jzt expresses
2 genes
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| rat |
Grin2a (24409) |
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| rat |
Grin2b (24410) |
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Mutation details: The transgene is designed to have ~8.5 kbp of the mouse Camk2a promoter sequences placed upstream of a chimeric NMDA glutamate receptor followed by an SV40 polyadenylation signal. Specifically, the N-terminal and transmembrane domain sequences from the rat Grin2a locus are fused with the C-terminal intracellular domain sequences from the rat Grin2b locus. Mice from the founder line with the highest expression in forebrain regions (cortex and hippocampus) were propagated. The investigator reports that Southern blots indicate only one copy of the transgene was integrated into the genome, and there is no evidence of multiple copies.
(J:223086)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:223086 Jacobs S, et al., Molecular and genetic determinants of the NMDA receptor for superior learning and memory functions. PLoS One. 2014;9(10):e111865 |
| All: |
1 reference(s) |
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Analysis Tools
