Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Shank3tm5.1Gfng
Name:	SH3 and multiple ankyrin repeat domains 3; targeted mutation 5.1, Guoping Feng
MGI ID:	MGI:5775650
Synonyms:	Shank3fx
Gene:	Shank3  Location: Chr15:89383826-89444464 bp, + strand  Genetic Position: Chr15, 44.96 cM
Alliance:	Shank3tm5.1Gfng page

Germline Transmission:	Earliest citation of germline transmission: J:229668
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, Null/knockout) Mutation:    Insertion   Mutation details: The targeting vector was designed with (from 5' to 3') an inward-facing lox2272:loxP site, an inverted Shank3 PDZ domain (exons 13-16), another inward-facing lox2272:loxP site and an FRT-flanked neomycin resistance cassette all replacing the corresponding endogenous Shank3 sequences. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:229668)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Shank3 Mutation:	77 strains or lines available

Original:	J:229668 Mei Y, et al., Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. Nature. 2016 Feb 25;530(7591):481-4
All:	4 reference(s)