Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sorbs2tm1.1Gfng
Name:	sorbin and SH3 domain containing 2; targeted mutation 1.1, Guoping Feng
MGI ID:	MGI:5775605
Synonyms:	Sorbs2F
Gene:	Sorbs2  Location: Chr8:45960825-46280943 bp, + strand  Genetic Position: Chr8, 25.44 cM
Alliance:	Sorbs2tm1.1Gfng page

Germline Transmission:	Earliest citation of germline transmission: J:231609
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The targeting vector was designed with a loxP::frt-SV40 promoter-Neo-pA-frt cassette 389 bp upstream of exon 12, and a loxP site 676 bp downstream of exon 12. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:231609)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sorbs2 Mutation:	79 strains or lines available

Original:	J:231609 Zhang Q, et al., Impaired Dendritic Development and Memory in Sorbs2 Knock-Out Mice. J Neurosci. 2016 Feb 17;36(7):2247-60
All:	3 reference(s)