Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Gabra1tm1.1Krmr
Name:	gamma-aminobutyric acid type A receptor subunit alpha 1; targeted mutation 1.1, Richard Kramer
MGI ID:	MGI:5763100
Synonyms:	alpha1-GABAsubA/subPhoRM, alpha1T125C, PhoRM
Gene:	Gabra1  Location: Chr11:42021766-42073757 bp, - strand  Genetic Position: Chr11, 24.97 cM
Alliance:	Gabra1tm1.1Krmr page

Germline Transmission:	Earliest citation of germline transmission: J:230569
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Single point mutation   Mutation details: The allele was designed to introduce a threonine-to-cysteine mutation at codon 152 (T152C counting from the start codon; or T125C in the mature peptide sequence) into exon 5 of the gene. The targeting vector also includes a loxP-flanked neomycin selection cassette upstream of exon 5, as well as a C-to-T silent mutation in the exon 5 DNA sequence (to create a HindIII site upstream of T152C for genotyping). Cre-mediated recombination removed the floxed neo cassette. (J:230569)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gabra1 Mutation:	47 strains or lines available

Original:	J:230569 Lin WC, et al., A Comprehensive Optogenetic Pharmacology Toolkit for In Vivo Control of GABA(A) Receptors and Synaptic Inhibition. Neuron. 2015 Dec 2;88(5):879-91
All:	3 reference(s)