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Gene Expression Data
Assay Details
Assay
Reference: J:61486 Littlewood Evans A, et al., Stereocilia defects in the sensory hair cells of the inner ear in mice deficient in integrin alpha8beta1. Nat Genet. 2000 Apr;24(4):424-8
Assay type: Immunohistochemistry
MGI Accession ID: MGI:5755672
Gene symbol: Ptk2
Gene name: PTK2 protein tyrosine kinase 2
Antibody: FAK antibody
Detection system: Secondary antibody coupled to fluorescein
Results
Specimen 4a +/-: embryonic day 16.0; Itga8tm1Lfr/Itga8+ (more )
Note: Double labeled: green - Ptk2; red - F-actin.
Structure Level Pattern Image Note
TS24: utricle epithelium Present Regionally restricted 4a +/- double , 4a +/- FAK Expression is at the apical hair cell surface.
Specimen 4a -/-: embryonic day 16.0; Itga8tm1Lfr/Itga8tm1Lfr (more )
Note: Double labeled: green - Ptk2; red - F-actin.
Structure Level Pattern Image Note
TS24: utricle epithelium Present Regionally restricted 4a -/- FAK , 4a -/- double Expression is in hair cells.
Specimen 4b +/-: postnatal day 0; Itga8tm1Lfr/Itga8+ (more )
Note: Double labeled: green - Ptk2; red - F-actin.
Structure Level Pattern Image Note
TS27: utricle epithelium Present Regionally restricted 4b +/- double , 4b +/- FAK Expression is concentrated at the apical hair cell surface.
Specimen 4b -/-: postnatal day 0; Itga8tm1Lfr/Itga8tm1Lfr (more )
Note: Double labeled: green - Ptk2; red - F-actin.
Structure Level Pattern Image Note
TS27: utricle epithelium Absent 4b -/- FAK , 4b -/- double
Specimen 4c +/-: postnatal day 0; Itga8tm1Lfr/Itga8+ (more )
Note: Double labeled: green - Ptk2; red - F-actin.
Structure Level Pattern Image Note
TS27: crista ampullaris Present 4c +/- FAK , 4c +/- double
Specimen 4c -/-: postnatal day 0; Itga8tm1Lfr/Itga8tm1Lfr (more )
Note: Double labeled: green - Ptk2; red - F-actin.
Structure Level Pattern Image Note
TS27: crista ampullaris Present 4c -/- double , 4c -/- FAK Expression in this mutant is the same as in wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory