Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Chn1tm2.2Ito
Name:	chimerin 1; targeted mutation 2.2, Shigeyoshi Itohara
MGI ID:	MGI:5754363
Synonyms:	Chn1alpha2KO
Gene:	Chn1  Location: Chr2:73441004-73605690 bp, - strand  Genetic Position: Chr2, 43.78 cM
Alliance:	Chn1tm2.2Ito page

Germline Transmission:	Earliest citation of germline transmission: J:229380
Parent Cell Line:	MS12 (ES Cell)
Strain of Origin:	C57BL/6NSlc

Allele Type:    Targeted (Modified isoform(s)) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 6. An additional loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 6. Western blot analysis confirmed the absence of isoform alpha 2 but continued expression of isoform alpha 1 in the hippocampus. (J:229380)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chn1 Mutation:	44 strains or lines available

Original:	J:229380 Iwata R, et al., RacGAP alpha2-chimaerin function in development adjusts cognitive ability in adulthood. Cell Rep. 2014 Sep 11;8(5):1257-64
All:	2 reference(s)