Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Thy1-env)E337Nath
Name:	transgene insertion E337, Avindra Nath
MGI ID:	MGI:5751973
Synonyms:	HERV-K env tg
Transgene:	Tg(Thy1-env)E337Nath  Location: unknown
Alliance:	Tg(Thy1-env)E337Nath page

Strain of Origin:

C57BL/6

Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Mutation details: The transgenic construct contains the 2.1kb codon optimized human endogenous retrovirus envelope protein, HERV-K env, gene under the control of the neuron specific mouse Thy1, thymus cell antigen 1, theta, gene promoter. Transgene expression is detected in cortical neurons (neuronal cell body cytoplasm and apical dendrites) and spinal cord by Western blot analysis and immunostaining, and in brain tissue by RT-PCR. (J:229381)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:229381 Li W, et al., Human endogenous retrovirus-K contributes to motor neuron disease. Sci Transl Med. 2015 Sep 30;7(307):307ra153
All:	1 reference(s)