Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Mbl1tm1.1(MBL2)Glst
Name:	mannose-binding lectin (protein A) 1; targeted mutation 1.1, Gregory L Stahl
MGI ID:	MGI:5705816
Gene:	Mbl1  Location: Chr14:40873415-40881558 bp, + strand  Genetic Position: Chr14, 22.36 cM
Alliance:	Mbl1tm1.1(MBL2)Glst page

Germline Transmission:	Earliest citation of germline transmission: J:217801
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Inserted expressed sequence, Null/knockout) Mutations:    Insertion, Intragenic deletion   Mbl1tm1.1(MBL2)Glst expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human MBL2 (4153) Mbl2  (MGI:96924)   Mutation details: A human MBL2 cDNA and FRT flanked neo cassette replaced a genomic region encompassing part of exon 2 and all of exons 3 and 4 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:217801)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mbl1 Mutation:	23 strains or lines available

Original:	J:217801 Pavlov VI, et al., Human mannose-binding lectin inhibitor prevents myocardial injury and arterial thrombogenesis in a novel animal model. Am J Pathol. 2015 Feb;185(2):347-55
All:	1 reference(s)