Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Adarb1tm1.2Eme
Name:	adenosine deaminase, RNA-specific, B1; targeted mutation 1.2, Ronald Emeson
MGI ID:	MGI:5700226
Synonyms:	Adar2 lox-ECS-lox
Gene:	Adarb1  Location: Chr10:77126560-77254104 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband C
Alliance:	Adarb1tm1.2Eme page

Germline Transmission:	Earliest citation of germline transmission: J:144148
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a loxP site upstream of the editing site complementary sequence (ECS) in intron 4, and a second loxP site followed by a loxP-flanked neomycin resistance (neo) cassette downstream of the ECS site in intron 4 of the gene. Cre-mediated recombination removed the floxed neo cassette. (J:144148)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adarb1 Mutation:	35 strains or lines available

Original:	J:144148 Feng Y, et al., Altered RNA editing in mice lacking ADAR2 autoregulation. Mol Cell Biol. 2006 Jan;26(2):480-8
All:	1 reference(s)