Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(CAG-GDF15)1377Elng
Name:	transgene insertion 1377, Thomas Eling
MGI ID:	MGI:5699702
Synonyms:	CAG-NAG-1, NAGTg+
Transgene:	Tg(CAG-GDF15)1377Elng  Location: unknown
Alliance:	Tg(CAG-GDF15)1377Elng page

Strain of Origin:

C57BL/6J

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(CAG-GDF15)1377Elng expresses 1 gene Transgene expresses: Organism Expressed Gene Homolog in Mouse Note human GDF15 (9518) Gdf15  (MGI:1346047)   Mutation details: The transgene contains a cDNA encoding human growth differentiation factor 15 (GDF15; also called NAG-1, nonsteroidal anti-inflammatory drug-activated gene) downstream of the "CAG promoter," which consists of the cytomegalovirus immediate early (CMV-IE) enhancer followed by the promoter, first exon and first intron of the chicken beta-actin gene, with the 3' splice junction sequence replaced by that of the rabbit hemoglobin beta gene. Immunoblot analysis with a rabbit antiserum recognizing human, but not mouse, GDF15 protein demonstrated high expression levels in skin, kidney, colon and brain, lower levels in lung, and no detectable expression in liver of transgenic mice. (J:120981)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:120981 Baek SJ, et al., Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia. Gastroenterology. 2006 Nov;131(5):1553-60
All:	9 reference(s)