Summary | Transgene origin | Transgene description | Expression | Find Mice (IMSR) | References

Symbol:	Tg(Ins1-HIST1H2BB/mCherry)5091Mhsg
Name:	transgene insertion 5091, Mark Huising
MGI ID:	MGI:5698910
Synonyms:	mIns1-H2b-mCherry
Transgene:	Tg(Ins1-HIST1H2BB/mCherry)5091Mhsg  Location: unknown
Alliance:	Tg(Ins1-HIST1H2BB/mCherry)5091Mhsg page

Strain of Origin:

(BALB/c x C57BL/6)F1

Transgene Type:    Transgenic (Reporter) Mutation:    Insertion   Mutation details: The transgene was designed with the murine insulin I (Ins1) promoter driving expression of an H2B-mCherry fusion protein (coding sequence for the human HIST1H2BB gene [histone 1 H2bb] with a C-terminal monomeric red fluorescent protein sequence). The founder was determined to transmit the transgene to approximately 75% of F1 offspring, indicative of 2 independent transgene insertion sites. One of these sites was subsequently determined to be silent and was bred out. Nuclear-localized mCherry fluorescence is observed in all pancreatic beta cells. Fluorescence is not seen in any other cells. (J:214617)

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:214617 Benner C, et al., The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non-coding RNA and protein-coding gene expression. BMC Genomics. 2014;15:620
All:	4 reference(s)