Pcdh15tm2.1Mll
Targeted Allele Detail
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| Symbol: |
Pcdh15tm2.1Mll |
| Name: |
protocadherin 15; targeted mutation 2.1 Ulrich Muller |
| MGI ID: |
MGI:5697806 |
| Synonyms: |
deltaCD2, exon38KO, PCDH15-deltaCD2 |
| Gene: |
Pcdh15 Location: Chr10:72935174-74485569 bp, + strand Genetic Position: Chr10, 37.43 cM
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| Alliance: |
Pcdh15tm2.1Mll page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:171627
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Modified isoform(s)) |
| Mutation: |
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Intragenic deletion
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Mutation details: An FRT-flanked neomycin selection cassette replaced exon 38. The neo cassette was subsequently removed by crossing the mice carrying the targeted allele to Flp-deleter mice. qPCR and in situ hybridization analyses of P1 homozygous mutant mice confirmed that expression of the CD2 isoform is abolished while expression of isoforms CD1 and CD3 is maintained.
(J:171627)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Pcdh15 Mutation: |
132 strains or lines available
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| Original: |
J:171627 Webb SW, et al., Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain. Development. 2011 Apr;138(8):1607-17 |
| All: |
2 reference(s) |
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Analysis Tools
