Tg(CAG-Bgeo,-MYC)1Saa
Transgene Detail
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| Symbol: |
Tg(CAG-Bgeo,-MYC)1Saa |
| Name: |
transgene insertion 1, Sarki A Abdulkadir |
| MGI ID: |
MGI:5695550 |
| Synonyms: |
Z-MYC |
| Transgene: |
Tg(CAG-Bgeo,-MYC)1Saa Location: unknown
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| Alliance: |
Tg(CAG-Bgeo,-MYC)1Saa page
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| Transgene Type: |
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Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter) |
| Mutation: |
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Insertion
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Tg(CAG-Bgeo,-MYC)1Saa expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
MYC (4609) |
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Mutation details: This transgene contains from 5' to 3', the CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter, a loxP-flanked STOP cassette (beta-galactosidase/neomycin resistance cassette [beta-geo] with three copies of the SV40 polyA termination signal) and the 1.8 kbp human myelocytomatosis oncogene cDNA sequence (MYC; including exons 2 and 3 and polyA site). The 10.8 kbp transgene was linearized and transfected into 129S/SvEv-derived embryonic stem (ES) cells. An ES cell clone with a single-copy transgene integration was selected for injection into blastocysts. Constitutive beta-galactosidase (lacZ) expression is directed to multiple tissue types. Removal of the STOP cassette by Cre-mediated recombination results in removal of lacZ and expression of MYC.
(J:114516)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:114516 Roh M, et al., Transgenic mice for Cre-inducible overexpression of the oncogenes c-MYC and Pim-1 in multiple tissues. Genesis. 2006 Oct;44(10):447-53 |
| All: |
4 reference(s) |
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Analysis Tools
