Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kcnmb2tm1.1Clin
Name:	potassium large conductance calcium-activated channel, subfamily M, beta member 2; targeted mutation 1.1, Christopher J Lingle
MGI ID:	MGI:5694679
Synonyms:	beta2floxed, kcnmb2 floxed
Gene:	Kcnmb2  Location: Chr3:31956656-32254329 bp, + strand  Genetic Position: Chr3, 15.48 cM
Alliance:	Kcnmb2tm1.1Clin page

Germline Transmission:	Earliest citation of germline transmission: J:225860
Parent Cell Line:	B6/BLU (ES Cell)
Strain of Origin:	C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 1 and a second loxP site downstream of exon 1 followed by an FRT-flanked neomycin resistance (neo) cassette which included a third loxP site, downstream of exon 1. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 1 floxed. (J:225860)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnmb2 Mutation:	17 strains or lines available

Original:	J:225860 Martinez-Espinosa PL, et al., Knockout of the BK beta2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity. J Gen Physiol. 2014 Oct;144(4):275-95
All:	2 reference(s)