Tg(TcraBC10,TcrbBC10)3Chi Transgene Detail MGI Mouse (MGI:5648061)

Tg(TcraBC10,TcrbBC10)3Chi
Transgene Detail

Summary

Symbol:	Tg(TcraBC10,TcrbBC10)3Chi
Name:	transgene insertion 3, Francis Chisari
MGI ID:	MGI:5648061
Synonyms:	BC10.3 TCR transgenic, Cor93 TCR transgenic
Transgene:	Tg(TcraBC10,TcrbBC10)3Chi Location: unknown
Alliance:	Tg(TcraBC10,TcrbBC10)3Chi page

Transgene
origin

Strain of Origin:

BALB/cByJ or C57BL/6J

Transgene
description

Transgene Type:

Transgenic (Inserted expressed sequence)

Mutation:

Insertion

Tg(TcraBC10,TcrbBC10)3Chi expresses 2 genes

Mutation details: Rearranged Valpha13.1 JalphaNEW06 and Vbeta8.1 Jbeta1.2 were obtained from K-restricted CD8<+> cytotoxic T lymphocyte clone BC10 which recognizes an epitope located between residues 93-100 in the hepatitis B virus core/nucleocapsid (COR93). TCR sequences were cloned into TCR cassette expression vectors (pTalpha and pTbeta) and co-injected. (J:213364)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

TCR expression cassettes into which the TCRalpha and TCRbeta cDNA sequences had been cloned were co-injected into (BALB/cByJ x C57BL/6J)F2 fertilized oocytes.

References

Original:	J:213364 Isogawa M, et al., CD40 activation rescues antiviral CD8(+) T cells from PD-1-mediated exhaustion. PLoS Pathog. 2013;9(7):e1003490
All:	6 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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