Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(TcraTcrb)1Lkm
Name:	transgene insertion 1, Linda Myers
MGI ID:	MGI:5648047
Transgene:	Tg(TcraTcrb)1Lkm  Location: unknown
Alliance:	Tg(TcraTcrb)1Lkm page

Strain of Origin:

FVB/N

Transgene Type:    Transgenic (Inserted expressed sequence) Mutation:    Insertion   Tg(TcraTcrb)1Lkm expresses 2 genes Transgene expresses: Organism Expressed Gene Note mouse Tcra (MGI:98553) mouse Tcrb (MGI:98578)   Mutation details: Rearranged Valpha2-Jalpha27 and Vbeta8.1 Jbeta2.4 fragments were obtained from an HLA-DRB1*0101 (DR1)-restricted A2-specific mouse T cell hybridoma (E168) by RT-PCR. The PCR fragments were subcloned into TCR cassette vectors pTalphacass and pTbetacass and co-injected. (J:223133)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available

Original:	J:223133 Tang B, et al., Characterization of T cell phenotype and function in a double transgenic (collagen-specific TCR/HLA-DR1) humanized model of arthritis. Arthritis Res Ther. 2014;16(1):R7
All:	3 reference(s)