Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pik3cbtm1.1Jdo
Name:	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; targeted mutation 1.1,Julian Downward
MGI ID:	MGI:5646522
Synonyms:	p110beta-RBD-DM
Gene:	Pik3cb  Location: Chr9:98920455-99022264 bp, - strand  Genetic Position: Chr9, 51.41 cM, cytoband E4
Alliance:	Pik3cbtm1.1Jdo page

Germline Transmission:	Earliest citation of germline transmission: J:198414
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Not Specified) Mutations:    Insertion, Nucleotide substitutions   Mutation details: S205D (AGT->GAT) and K224A (AAA->GCA) point mutations were introduced to the catalytic subunit of the gene and an FRT-flanked neomycin selection cassette was inserted in intron 6. The neomycin selection cassette was excised through crosses with Tg(ACTFLPe)9205Dym deleter mice, leaving a single FRT site in intron 6/7. (J:198414)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pik3cb Mutation:	151 strains or lines available

Original:	J:198414 Fritsch R, et al., RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms. Cell. 2013 May 23;153(5):1050-63
All:	2 reference(s)