Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Krastm3Bbd
Name:	Kirsten rat sarcoma viral oncogene homolog; targeted mutation 3, Mariano Barbacid
MGI ID:	MGI:5645350
Synonyms:	KrasFSFG12V
Gene:	Kras  Location: Chr6:145162425-145195965 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Alliance:	Krastm3Bbd page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, Humanized sequence, Null/knockout) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A targeting vector was designed to insert a FRT site flanked neomycin resistance gene and STOP cassette upstream of the ATG initiation codon into intron 1 and glycine codon 12 (GGT) in exon 2 was changed to valine (GTA) (p.G12V), a mutation commonly found in human tumors. (J:101977)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kras Mutation:	76 strains or lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	9 reference(s)