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Gene Expression Data
Assay Details
Assay
Reference: J:175980 Mortensen AH, et al., Candidate genes for panhypopituitarism identified by gene expression profiling. Physiol Genomics. 2011 Oct 6;43(19):1105-16
Assay type: RNA in situ
MGI Accession ID: MGI:5641342
Gene symbol: Otx2
Gene name: orthodenticle homeobox 2
Probe: Otx2 probe30
Probe preparation: labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 3Aa: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: diencephalon Present Regionally restricted 3Aa Expression in ventral diencephalon.
TS17: Rathke's pouch Present 3Aa Expression in invaginated oral ectoderm.

Specimen 3Ac: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: diencephalon Present Regionally restricted 3Ac Expression persists in region of ventral diencephalon.

Specimen 3Ad: embryonic day 12.5; Prop1df/Prop1df (more )
Structure Level Pattern Image Note
TS20: diencephalon Present Regionally restricted 3Ad Expression in ventral diencephalon.

Specimen 3Ae: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: diencephalon Present Regionally restricted 3Ae Expression in ventral diencephalon.
TS22: remnant of Rathke's pouch Absent 3Ae
TS22: neurohypophysis pars nervosa Present 3Ae Expression in forming posterior lobe.

Specimen 3Af: embryonic day 14.5; Prop1df/Prop1df (more )
Structure Level Pattern Image Note
TS22: diencephalon Present Regionally restricted 3Af Expression in ventral diencephalon.
TS22: neurohypophysis pars nervosa Present 3Af Expression in forming posterior lobe.

Specimen 3Ag: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: diencephalon Absent 3Ag No expression in ventral diencephalon or any pituitary gland lobe.
TS24: pituitary gland Absent 3Ag No expression in ventral diencephalon or any pituitary gland lobe.

Specimen 3Ah: embryonic day 16.5; Prop1df/Prop1df (more )
Structure Level Pattern Image Note
TS24: adenohypophysis pars intermedia Strong 3Ah Elevated expression throughout dysmorphic intermediate lobe.
TS24: neurohypophysis pars nervosa Absent 3Ah No ectopic expression in posterior lobe.

Specimen 3Ai: postnatal day 1 (more )
Structure Level Pattern Image Note
TS27: diencephalon Absent 3Ai No expression in ventral diencephalon or any pituitary gland lobe.
TS27: pituitary gland Absent 3Ai No expression in ventral diencephalon or any pituitary gland lobe.

Specimen 3Aj: postnatal day 1; Prop1df/Prop1df (more )
Structure Level Pattern Image Note
TS27: adenohypophysis pars anterior Present Regionally restricted 3Aj Ectopic expression in both anterior and intermediate lobes.
TS27: adenohypophysis pars intermedia Present Regionally restricted 3Aj Ectopic expression in both anterior and intermediate lobes.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory