Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Esyt2tm1Sud
Name:	extended synaptotagmin-like protein 2; targeted mutation 1, Thomas C Sudhof
MGI ID:	MGI:5636380
Synonyms:	2EN
Gene:	Esyt2  Location: Chr12:116244816-116354670 bp, + strand  Genetic Position: Chr12, Syntenic
Alliance:	Esyt2tm1Sud page

Germline Transmission:	Earliest citation of germline transmission: J:101977
Parent Cell Line:	ART B6-3, B6-3 (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A targeting vector is designed to insert an F3 site followed by a loxP site upstream of exon 10. Inserted downstream of exon 10, from 5' to 3' , are a second loxP site, a FRT site, a neomycin resistance cassette, a second F3 site, a loxP2272 site, and a mutated exon 10 with four aspartate residues mutated into alanine residues (D4A) followed by a second loxP2272 site and a second FRT site. (J:101977)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esyt2 Mutation:	43 strains or lines available

Original:	J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:	2 reference(s)