Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Picalmtm1.1Tmae
Name:	phosphatidylinositol binding clathrin assembly protein; targeted mutation 1.1, Takahiro Maeda
MGI ID:	MGI:5636370
Synonyms:	PicalmF
Gene:	Picalm  Location: Chr7:89779418-89858655 bp, + strand  Genetic Position: Chr7, 50.47 cM
Alliance:	Picalmtm1.1Tmae page

Germline Transmission:	Earliest citation of germline transmission: J:220728
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The targeting vector contains an FRT-flanked PGK-neo cassette, in reverse orientation, and a 3' loxP site downstream of exon 2, and another loxP site inserted upstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 2 floxed. (J:220728)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Picalm Mutation:	42 strains or lines available

Original:	J:220728 Ishikawa Y, et al., Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology. Haematologica. 2015 Apr;100(4):439-51
All:	3 reference(s)